Riboflavin ampoules. Riboflavin: instructions for use

In the article, we will consider the drug "Riboflavin", instructions for use for drops and tablets, as well as analogues and reviews about the medicine.

The drug is which is often called the most important in matters of preserving beauty. The quality and properties of the epidermis depend on the content of this substance in the body. In addition, this vitamin has a positive effect in the treatment of disorders in many body systems.

Composition and properties

As the instructions for use indicate, "Riboflavin" is a monopreparation, which includes one component - 6,7-Dimethyl-9-(D-1-ribityl)-isoalloxazine, also called vitamin B2.

The drug is produced in various forms, including powder, dragee, tablets and drops.

It has the ability to quickly absorb and dissolve in water. It interacts with other trace elements and plays an important role in human health. B2, like other vitamins of this group, takes an active part in the process of metabolism of fats, proteins and carbohydrates, and also contributes to the production of energy by the body in the required amount.

"Riboflavin" is a unique drug that improves the production of red blood cells, and also allows you to saturate the blood with oxygen during breathing.

Among other things, vitamin B2 contributes to the production of antibodies and is directly involved in regulating the growth of the body, as well as its reproductive function. No less significant is "Riboflavin" for the health and condition of human skin, as well as the growth of nails and hair, general health in general and the normal functioning of the thyroid gland. Vitamin B2 acts as a prophylactic for eye diseases, including certain types of cataracts.

Indications and contraindications

What else does the user manual tell us? "Riboflavin" is mainly prescribed for the treatment of hypo- and ariboflavinosis. In addition, the drug is used in combination with other drugs to treat the following diseases:

• Hemeralopia, characterized by deterioration of vision at night and in the evening. The drug is prescribed in combination with "Retinol"
• Conjunctivitis, accompanied by an inflammatory process in the outer eye membrane.
• Iritis, in which the iris is inflamed.
• Keratitis.
• Wounds and ulcers of various origins that do not heal for a long time.
• Radiation sickness caused by exposure to ionizing radiation.
• Eczema.
• Botkin's disease.
• Disorder in the work of the gastrointestinal tract.
• Anemia of iron deficiency type.

According to the instructions for "Riboflavin", a contraindication for its use is an individual reaction to the active ingredient, that is, intolerance to vitamin B2.

Instructions for tablets

In accordance with the instructions for use for tablets "Riboflavin", the following regimen is provided for them:

• With vitamin B2 deficiency in the body, adults are prescribed from 5 to 30 mg of the drug per day, divided into several doses.
• For the prevention of migraine, 4 mg per day is taken. Treatment can last for several months, until a steady positive trend appears.
• According to the instructions for the use of "Riboflavin", special drops or tablets are used for the eyes at a dosage of 2-3 mg per day. This is necessary for the prevention of cataracts and other diseases.

Quite often, riboflavin is prescribed in combination with niacin, based on the proportions of 3 mg of vitamin B2 to 40 mg of niacin. The daily dosage of the drug also depends on the age of the patient:

• From birth to six months, it is recommended to give the child 0.3 mg.
• Up to a year, the daily dosage is 0.4 mg.
• From one year to three years of age, the daily dosage is increased to 0.5 mg.
• From four to eight years, 0.6 mg is prescribed.
• At the age of nine to 13 years - 0.9 mg.

The dosage regimen also differs by gender:

• Men from the age of 14 are prescribed 1.3 mg of the vitamin per day.
• Women from 14 to 18 years old should take 1 mg of the drug.
• Starting from the age of 18, the dosage for women increases to 1.1 mg.
• During the period of bearing a child, a woman is prescribed a vitamin intake in the amount of 1.4 mg per day.
• During breastfeeding, the drug is taken by a woman at 1.6 mg.

Drops and ampoules

As the instructions for use indicate, eye drops "Riboflavin" is a solution at a concentration of 0.01%. The drug is prescribed for the treatment of diseases in the field of ophthalmology of various origins. In this case, a standard dosing regimen is used - one instillation in each eye in the morning and evening. So it says in the instructions for use for eye drops "Riboflavin". The course of treatment is determined by the attending physician, depending on the severity of the disease and its form.

According to the instructions for use, "Riboflavin-Mononucleotide" is produced in the form of ampoules with a solution for intramuscular injection. In addition, the drug can be diluted in water for injection and administered intravenously. For intramuscular administration, adults use a dosage of 1 ml of a 1% solution per day. Treatment should continue for at least 10 and no more than 20 days.

When prescribing injections by a doctor, the instructions for use for "Riboflavin" must be strictly observed. The pediatric dosage is 0.005-0.01 g. At the initial stage of therapy, injections are given daily for 3-5 days, followed by the second stage, which involves injections every other day or two. Instructions for use for "Riboflavin" is very detailed, it describes in detail all the issues related to the dosage of the drug.

special instructions

In most cases, the use of "Riboflavin" is not accompanied by any undesirable reactions from the body. It is extremely rare to observe an allergic reaction to the drug. In exceptional cases, there may be a violation of the functioning of the liver, as well as visual impairment.

Overdose

An overdose of riboflavin is practically impossible. Most often, the drug is well tolerated by the body of patients of different age groups. Extremely rarely, excess dosages can lead to skin rashes and itching.

drug interaction

The issue of compatibility of vitamin B2 with other drugs has been studied quite well. Doctors pay attention to the fact that the use of alcohol simultaneously with the use of "Riboflavin" reduces the absorption of the drug in the intestine, and, accordingly, the effectiveness of the vitamin therapy is reduced.

Similarly, tricyclic antidepressants and phenothiazines affect the absorption of vitamin B2. By decision of the attending physician, the dosage of the drugs can be adjusted.

The absorption of vitamin B2 is reduced when taken with probenecid. This combination may also require a change in the dosage of both drugs.

Analogues

"Riboflavin" has a fairly large list of similar drugs. These are mainly medicines for the treatment of problems in the field of ophthalmology. The most common among them are:

• "Sofradex".
• "Vial".
• Wigamox.
• "Cyloxane".
• "Systein-Ultra".
• "Xalacom".
• "Korneregel".
• "Vitabakt".
• "Oftarimin".
• "Taurine".
• "Catalin".
• "Tobradex".
• "Optinol".
• "Vizin".
• "Khrustalin".

All these drugs are similar to "Riboflavin" in terms of their effect, but their composition is different.

Gross formula

Pharmacological group of the substance Riboflavin

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Riboflavin

Vitamin B 2. Yellow-orange crystalline powder of bitter taste, with a slight specific odor, is unstable in the light. Slightly soluble in water and alcohol. Aqueous solutions have a yellowish color.

Pharmacology

Substratively activates the synthesis of flavin coenzymes, interacts with ATP, forms flavin mononucleotide and flavin adenine dinucleotide, which are involved in proton transfer and regulation of redox processes. Chemically pure riboflavin and its nucleotides are quickly absorbed in the gastrointestinal tract, absorption is slowed down by various inflammatory processes in the intestine, circulatory disorders, achilia, chronic gastritis, enteritis; in young children, absorption is slower than in adults. The distribution in the body is uneven: the largest number is found in the myocardium, liver, and kidneys. It is excreted mainly in the urine unchanged; with a normal vitamin content in the body, about 9% of the administered dose is excreted in the urine per day, and the rest is reabsorbed in the kidney tubules; with excessive administration, excretion increases and urine turns yellow. Elimination of riboflavin is increased in thyrotoxicosis.

Plays an important role in metabolism, participates in growth processes. The daily requirement for an adult is 2.5 mg, with heavy physical labor - about 3 mg; for children from 6 months to 1 year - 0.6 mg, 1-1.5 years - 1.1 mg, from 1.5-2 years - 1.2 mg, 3-4 years - 1.4 mg, 5 -6 years old - 1.6 mg, 7-10 years old - 1.9 mg, 11-13 years old - 2.3 mg, 14-17 years old: for boys - 2.5 mg, for girls - 2.2 mg.

Supports the process of phagocytosis, affects the morphology and function of the central and autonomic nervous system, plays an important role in maintaining normal visual function of the eye and in the synthesis of erythropoietin, hemoglobin. It somewhat increases the secretory function of the stomach (participates in the formation of hydrochloric acid of gastric juice), improves bile secretion, facilitates the absorption of carbohydrates in the small intestine, and is necessary to maintain normal intestinal microflora. Helps to improve the glycogen-fixing, synthetic, antitoxic function of the liver, increases the sensitivity of liver cells to the action of insulin, promotes insulin incretion. Normalizes the level of bilirubin in the blood (hepatitis A).

Application of the substance Riboflavin

Hypo- and ariboflavinosis of exogenous and endogenous origin, hemeralopia, conjunctivitis, iritis, keratitis, corneal clouding, cataracts, long-term non-healing wounds and ulcers, radiation sickness, asthenia, cheilitis, angular stomatitis (jamming), glossitis, itchy dermatosis, eczema, neurodermatitis, photodermatosis, seborrhea, red acne, candidiasis, viral hepatitis A, chronic hepatitis, cirrhosis of the liver, gastrointestinal dysfunction, sprue, malnutrition, anemia, leukemia. For preventive purposes - reduced absorption from the gastrointestinal tract, intensive elimination and increased need for riboflavin (acute and chronic hypoxia, respiratory and heart failure, burn disease, frostbite, protein deficiency and excess carbohydrate nutrition, acute infectious diseases, including in the treatment antimicrobial agents that suppress gram-negative intestinal flora, phototherapy).

Contraindications

Hypersensitivity, nephrolithiasis.

Side effects of riboflavin

Visual disturbances, kidney function, allergic reactions.

Interaction

Aminazin, imizin, amitriptyline disrupt (blockade of flavinokinase) the inclusion of riboflavin in flavin mononucleotide, flavin adenine dinucleotide and increase its excretion in the urine. When combined with thyroid hormones, metabolism is accelerated. Under the influence of m-anticholinergics, absorption and bioavailability increase (due to a slowdown in intestinal motility). Compatible with antianemic agents, antihypoxants, anabolics. Prevents or reduces the undesirable effects of chloramphenicol (impaired hematopoiesis, optic neuritis). Possible decrease in the activity of tetracyclines.

Riboflavin INN (solution for intramuscular administration)

International name: Riboflavin

Dosage form: solution for intramuscular injection.

Chemical Name:

7, 8 - dimethyl - 10 - (D - 1 - ribityl) isoalloxazine (as sodium monophosphate)

Pharmachologic effect:

Vitamin B2; has a metabolic effect; interacts with ATP, forming flavin protein coenzymes - flavin adenine mononucleotide and flavin adenine dinucleotide, which are components of such enzymes as succinate dehydrogenase, cytochrome reductase, diaphorase, amino acid oxidases, etc. By regulating redox processes, it takes part in H + transfer, tissue respiration, carbohydrate, protein and fat metabolism , in maintaining the normal visual function of the eye, the synthesis of Hb and erythropoietin. Riboflavin-activated pyridoxalkinase converts pyridoxine (vitamin B6) to its active form, pyridoxal phosphate. Promotes the conversion of tryptophan to niacin, maintaining the integrity of red blood cells. It is part of glutathione reductase, xanthine oxidase. It is synthesized by normal intestinal microflora and is itself necessary for its maintenance.

Pharmacokinetics:

Rapidly absorbed from the gastrointestinal tract (mainly from the duodenum). Chronic gastritis, enteritis, achilia, malabsorption, ethanol slow absorption. Communication (mainly in the form of metabolites - flavin adenine mononucleotide and flavin adenine dinucleotide) with plasma proteins - 60%. Distributed throughout all organs and tissues, deposited in muscle tissue, liver, spleen, kidneys and myocardium. Penetrates through the placenta and into breast milk. Metabolized in the liver. T1 / 2 - 66-84 min. It is excreted by the kidneys, almost completely in the form of metabolites, when taken in high doses - mainly unchanged. Small amounts are excreted in the feces. It is excreted by hemodialysis, but much more slowly than by renal excretion.

Indications:

Hypo- and avitaminosis B2, as well as conditions of increased body demand for vitamin B2: hemeralopia, corneal vascularization, conjunctivitis, blepharitis, photophobia, inadequate and unbalanced nutrition (including parenteral), malabsorption, pregnancy (especially with nicotine and drug addiction, multiple pregnancy), lactation period, angular stomatitis, cheilosis, dermatosis, seborrheic dermatitis, glossitis, dysbacteriosis, depression of bone marrow hematopoiesis, anemia (normocytic, normochromic), neuropathy, burns, prolonged fever, gastrectomy, diseases of the hepatobiliary tract ( obstructive jaundice, cirrhosis, including alcoholic), phototherapy, malnutrition, neonatal hyperbilirubinemia, hyperthyroidism, chronic infectious diseases, gastrointestinal diseases (tropical sprue, celiac disease, Crohn's disease, persistent diarrhea), malignant tumors, prolonged stress, simultaneous use phenothiazines, tricyclic antidepressants, drugs that block tubular secretion.

Contraindications:

Hypersensitivity.

Dosing regimen:

Side effects:

Rarely - allergic reactions.

Special instructions:

Colors urine light yellow. Foods rich in vitamin B2 are yeast, liver, kidneys, milk, egg yolk, peanuts, cheese, cottage cheese, mushrooms, kefir, mackerel, cod, meat, peas, leafy vegetables, germs and shells of cereals. It should be borne in mind that riboflavin is destroyed under the influence of the rays of the blue part of the solar spectrum (about 450 nm). At present, the effectiveness of riboflavin for the treatment of acne vulgaris, burning feet syndrome, congenital methemoglobinemia, migraine headaches, and muscle spasms has not been proven.

Interaction:

Reduces the activity of doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin. Incompatible with streptomycin. Chlorpromazine, imipramine, amitriptyline, due to the blockade of flavinokinase, disrupt the incorporation of riboflavin into flavin adenine mononucleotide and flavin adenine dinucleotide and increase its excretion in the urine. Ethanol, tricyclic antidepressants, phenothiazines, drugs that block tubular secretion reduce absorption (require an increase in the dose of riboflavin). M-anticholinergics increase absorption and bioavailability (reduce intestinal motility). Thyroid hormones speed up metabolism. Reduces and prevents side effects of chloramphenicol (impaired hematopoiesis, optic neuritis). Compatible with drugs that stimulate hematopoiesis, antihypoxants, anabolic steroids.

Riboflavin is vitamin B2.

pharmachologic effect

Vitamin B2 in a healthy person is produced by the intestinal microflora, it is important for the implementation of vital redox processes, carbohydrate, protein and fat metabolism.

The beneficial properties of Riboflavin also include the fact that it promotes the production of hemoglobin, serotonin, neurotransmitters, corticosteroids, red blood cells, maintains normal visual function, gives nails, hair and skin a healthy look. Without vitamin B2, vitamin K, folic acid, vitamin B6, iron are not absorbed.

The daily rate of Riboflavin for an adult is 1.5-2.0 mg; for children 1-10 years old. - 0.5-1.2 mg; children 11-17 years old. - 1.2-2.0 mg.

The appearance of sores on the mucous membranes and skin, cracks in the corners of the mouth, acne, weakness in the muscles, cataracts, as well as blurred vision, especially at night, and rapid fatigue indicate a lack of vitamin.

Natural sources of vitamin B2 are: dairy products, cabbage, spinach, eggs, liver, fish, meat, carrots, lettuce.

Release form

Riboflavin is available in tablets and as a solution for injection.

Indications for the use of Riboflavin

The drug is prescribed for vitamin B2 deficiency and with an increased need for this substance in such conditions:

• hemeralopia (impaired twilight vision);
• conjunctivitis;
• photophobia;
• blepharitis;
• corneal vascularization;
• malabsorption;
• pregnancy and lactation;
• poor nutrition;
• anemia;
• burns;
• condition after gastrectomy (surgery to remove the stomach or part of it);
• dermatosis;
• glossitis;
• dysbacteriosis and dysfunction of the intestine;
• malignant neoplasms;
• stress;
• hyperthyroidism.

The restorative properties of Riboflavin are used in diseases of the liver and gastrointestinal tract.- it is prescribed for cirrhosis of the liver, obstructive jaundice, neonatal hyperbilirubinemia, Crohn's disease, enteropathy.

Instruction Riboflavin: method of application

The standard daily dosage of Riboflavin tablets for adults is 5-10 mg. If the disease is severe, you can prescribe the patient 15-30 mg in three divided doses.

Children can be given 2-5 mg per day once. Take vitamin B2 tablets for one or one and a half months.

Dosage of Riboflavin in solution for intramuscular injections: adults for 10-15 days are injected with 1 ml 1 time per day; children - 1 ml per day for 3-5 days. After this time, the drug is injected 2-3 times a week. The instructions for Riboflavin indicate that for a full course, 15-20 injections should be given.

In case of eye diseases, 0.2-0.5 ml of Riboflavin 1% solution is injected to the patient for 10-15 days.

Side effects

After the use of Riboflavin, the patient may have impaired vision or kidney function, and allergies may also begin.

It is believed that an overdose of Riboflavin is impossible, since its excess is excreted naturally every day, and it does not tend to accumulate. For this reason, it is recommended to regularly take vitamin B2 as a preventive measure.

Contraindications

Riboflavin according to the instructions is contraindicated in nephrolithiasis, hypersensitivity.

Pregnant and lactating women can take vitamin B2.

When using Riboflavin, take into account that it reduces the effectiveness of tetracycline, lincomycin, erythromycin, oxytetracycline, doxycycline.

The detoxifying properties of Riboflavin are enhanced when combined with nicotinic acid.

The bioavailability of the vitamin increases in combination with m-anticholinergics.

You can not take vitamin B2 at the same time as streptomycin.

Sincerely,

Tradename:
Riboflavin

International non-proprietary name:

Chemical Name:
(7, 8 - Dimethyl-10- (D - ribo- 2, 3, 4, 5 - tetraoxypentyl) azoalloxazine

Dosage form:

Compound:

Description
Flat-cylindrical tablets of yellow color, with risk and chamfer. On the surface of the tablets, inclusions of a darker color are allowed.

Pharmacotherapeutic group:

ATX Code- A11HA04

Pharmacological properties
Vitamin B 2, regulating redox processes, is involved in protein, fat and carbohydrate metabolism, as well as in maintaining normal visual function of the eye and hemoglobin synthesis.

Indications for use
Hypo- and avitaminosis of vitamin B2; hemeralopia, conjunctivitis, iritis, keratitis, corneal ulcers, cataracts, inadequate and unbalanced nutrition, asthenic conditions. In the complex therapy of long-term non-healing wounds and ulcers, radiation sickness, with impaired bowel function.

Contraindications
Hypersensitivity to the components of the drug.

Dosage and administration
A single therapeutic dose for adults: 0.005 - 0.01 g (5-10 mg) per day, in more severe cases - 0.01 g 3 times a day for 1-1.5 months.
Children are prescribed 0.002-0.005 g and up to 0.01 g per day, depending on age.

Side effect
Allergic reactions are possible.

special instructions
It is possible to stain urine yellow (completely harmless).

Release form
Tablets 2 mg, 5 mg, 10 mg. 50 tablets in a jar or 10, 20 or 25 tablets in a blister pack. Each bank or 1, 2, 3 or 5 blister packs together with instructions for use in a pack of cardboard.

Storage conditions
In a dry, dark place, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date
3 years. The drug should be used before the date indicated on the package.

Terms of dispensing from pharmacies
Over the counter.

Manufacturer
Republican Unitary Enterprise "Borisov Plant of Medical Preparations",
Republic of Belarus, Minsk region, Borisov, st. Chapaev, 64/27.